Sodium valproate-related hyperammonaemic encephalopathy
نویسندگان
چکیده
منابع مشابه
Non-hyperammonaemic valproate encephalopathy after 20 years of treatment
Sodium valproate is a commonly used antiseizure drug with broad indications for different seizuretypes and epilepsy syndromes. Well-recognised side effects include weight gain, tremor, dizziness, and unsteadiness. Non-hyperammonaemic parkinsonism, with or without cognitive impairment, is a rare adverse effect of sodium valproate. We present the case of a sixty year-old lady with a generalized s...
متن کاملAcute hyperammonaemic encephalopathy
Peng Soon Ng1,*, Choie Cheio Tchoyoson Lim2 and Nigel CK Tan1 Department of Neurology, National Neuroscience Institute, Singapore, Singapore and Department of Neuroradiology, National Neuroscience Institute, Singapore, Singapore *Correspondence address. Department of Neurology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433. Tel: þ65-63577171; Fax: þ65-63577137; E-mai...
متن کاملValproic acid induced hyperammonaemic encephalopathy.
OBJECTIVE To observe clinical and laboratory features of valproic acid-induced hyperammonaemic encephalopathy in patients taking valproic acid. METHODS Observational study was conducted at the Neurology Department, Dow University of Health Sciences, Civil Hospital, Karachi, from February 26, 2010 to March 20, 2011. Ten patients on valproic acid therapy of any age group with idiopathic or seco...
متن کاملHyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine transcarbamylase deficiency.
Ornithine transcarbamylase deficiency is an X linked disorder and the most common inherited cause of hyperammonaemia. Fluctuating concentrations of ammonia, glutamine, and other excitotoxic amino acids result in a chronic or episodically recurring encephalopathy. A heterozygous female patient first presented with protein intolerance, attacks of vomiting, and signs of mental retardation in early...
متن کاملMechanism for Valproate Encephalopathy
Sin,—Hyperglycinsemia, hyperglycinuria,l propionicaciduria2 and Reye’s syndrome3 have been reported in epileptic patients taking the anticonvulsant drug valproic acid (VPA). While investigating possible mechanisms of VPA toxicity we found increased plasma glycine and propionic acid concentrations in symptom-free patients taking VPA (table i). With informed consent, loading tests with 500 ...
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ژورنال
عنوان ژورنال: Case Reports
سال: 2014
ISSN: 1757-790X
DOI: 10.1136/bcr-2014-203899